Johnny Depp character Ed Wood
Martin Landau character Bela Lugosi
Sarah Jessica Parker character Dolores Fuller
Patricia Arquette character Kathy O'Hara
Jeffrey Jones character Criswell
Bill Murray character Bunny Breckinridge
Lisa Marie character Vampira
George Steele character Tor Johnson
G. D. Spradlin character Reverend Lemon
Vincent D'Onofrio character Orson Welles
Mike Starr character Georgie Weiss
Max Casella character Paul Marco
Brent Hinkley character Conrad Brooks
William James Myers character Tor Johnson
Juliet Landau character Loretta King
Clive Rosengren character Ed Reynolds
Norman Alden character Cameraman Bill (uncredited)
Leonard Termo character Makeup Man Harry (uncredited)
Ned Bellamy character Dr. Tom Mason (uncredited)
Danny Dayton character Soundman (uncredited)
Ross Manarchy character Camera Assistant (uncredited)
Bill Cusack character Tony McCoy
Stanley DeSantis character Mr. Feldman (uncredited)
Biff Yeager character Rude Boss (uncredited)
Joseph R. Gannascoli character Security Guard (uncredited)
Carmen Filpi character Old Crusty Man (uncredited)
Lisa Malkiewicz character Secretary #1 (uncredited)
Melora Walters character Secretary #2 (uncredited)
Conrad Brooks character Bartender (uncredited)
Don Amendolia character Salesman (uncredited)
Reid Cruickshanks character Stage Guard (uncredited)
Lionel Decker character Executive #1 (uncredited)
Edmund L. Shaff character Executive #2 (uncredited)
Gene LeBell character Ring Announcer (uncredited)
Bobby Slayton character TV Show Host (uncredited)
Gretchen Becker character TV Host's Assistant (uncredited)
John Rice character Conservative Man (uncredited)
Catherine Butterfield character Conservative Wife (uncredited)
Mary Portser character Backer's Wife (uncredited)
King Cotton character Hick Backer (uncredited)
Don Hood character Southern Backer (uncredited)
Matthew Barry character Valet (uncredited)
Ralph Monaco character Waiter (uncredited)
Anthony Russell character Busboy (uncredited)
Gregory Walcott character Potential Backer (uncredited)
Charles C. Stevenson Jr. character Another Backer (uncredited)
Rance Howard character Old Man McCoy (uncredited)
Vasek Simek character Professor Strowski (uncredited)
Vinny Argiro character TV Horror Show Director (uncredited)
Korla Pandit character Indian Musician (uncredited)
Patti Tippo character Nurse (uncredited)
Ray Baker character Doctor (uncredited)
Louis Lombardi character Rental House Manager (uncredited)
Jesse Hernandez character Wrestling Opponent (uncredited)
Jim Boyce character Theatre Manager (uncredited)
Ben Ryan Ganger character Angry Kid (uncredited)
Charlie Holliday character Tourist (uncredited)
Tommy Bertelsen character Tough Boy (uncredited)
Adam Drescher character Photographer #1 (uncredited)
Ric Mancini character Photographer #2 (uncredited)
Daniel Riordan character Pilot / Strapping Young Man (uncredited)
Mickey Cottrell character Hammy Alien (uncredited)
Lena Banks character Sexy Pedestrian (uncredited)
Maurice LaMarche character Orson Welles (voice) (uncredited)
Ada Tai character Vampira's Friend (uncredited)
Arlene Tai character Vampira's Friend (uncredited)
Rayder Woods character Car Vandal (uncredited)
Ralph Moratz character Extra (uncredited)
