Steve Carell character Gru / Dru (voice)
Kristen Wiig character Lucy Wilde (voice)
Trey Parker character Balthazar Bratt (voice)
Miranda Cosgrove character Margo (voice)
Dana Gaier character Edith (voice)
Nev Scharrel character Agnes (voice)
Steve Coogan character Fritz / Silas Ramsbottom (voice)
Julie Andrews character Gru's Mom (voice)
Jenny Slate character Valerie Da Vinci (voice)
Pierre Coffin character Minions / Museum Director / Additional Voice (voice)
Chris Renaud character Additional Minions (voice)
Andy Nyman character Clive the Robot (voice)
Michael Beattie character The Scar Faced Man / TMZ Announcer (voice)
Tara Strong character Additional Voice (voice)
Adrian Ciscato character Niko (voice)
Brian T. Delaney character Commercial Announcer / Military Officer / Additional Voice (voice)
Ken Daurio character Celebrity (voice)
Lori Alan character Additional Voice (voice)
Carlos Alazraqui character Additional Voice (voice)
Kyle Balda character Additional Voice (voice)
Teresa Ganzel character Additional Voice (voice)
Bob Bergen character Additional Voice (voice)
Jess Harnell character Additional Voice (voice)
Gregg Berger character Additional Voice (voice)
John Kassir character Additional Voice (voice)
Mona Marshall character Additional Voice (voice)
John Cygan character Additional Voice (voice)
Laraine Newman character Additional Voice (voice)
Jan Rabson character Additional Voice (voice)
Bill Farmer character Additional Voice (voice)
Mindy Sterling character Additional Voice (voice)
Danny Mann character Additional Voice (voice)
Jim Ward character Additional Voice (voice)
Matthew Wood character Additional Voice (voice) (uncredited)
Katia Saponenko character Niko's Mother (voice)
Jude Alpers character Commercial Kid (voice)
Cory Walls character Vincenzo (voice)
Sophie M. Siadatpour character Little Girl (voice)
Stephanie De Meautis character Additional Voice (voice)
Bruno Dequier character Additional Voice (voice)
Martavious Gayles character Additional Voices (voice)
Gregg Berger character Additional Voices (voice)
Tara Strong character Additional Voices (voice)