Steve Carell character Gru (voice)
Kristen Wiig character Lucy (voice)
Benjamin Bratt character Eduardo Pérez / El Macho (voice)
Miranda Cosgrove character Margo (voice)
Russell Brand character Dr. Nefario (voice)
Ken Jeong character Floyd Eagle-san (voice)
Steve Coogan character Silas Ramsbottom (voice)
Elsie Fisher character Agnes (voice)
Dana Gaier character Edith (voice)
Moisés Arias character Antonio Pérez (voice)
Nasim Pedrad character Jillian (voice)
Kristen Schaal character Shannon (voice)
Pierre Coffin character Kevin the Minion / Bob the Minion / Stuart the Minion / Additional Minions / Evil Minions (voice)
Chris Renaud character Additional Minions / Evil Minions / Italian Waiter (voice)
Nickolai Stoilov character Arctic Lab Guards (voice)
Vanessa Bayer character Flight Attendant (voice)
Ava Acres character Additional Voices (voice)
Lori Alan character Additional Voices (voice)
Jack Angel character Additional Voices (voice)
Eva Bella character Additional Voices (voice)
Georgia Cook character Additional Voices (voice)
John Cygan character Additional Voices (voice)
Debi Derryberry character Additional Voices (voice)
Jess Harnell character Additional Voices (voice)
Danny Mann character Additional Voices (voice)
Mona Marshall character Additional Voices (voice)
Mickie McGowan character Additional Voices (voice)
Mason McNulty character Additional Voices (voice)
Alec Medlock character Additional Voices (voice)
Laraine Newman character Additional Voices (voice)
Jan Rabson character Additional Voices (voice)
Andre Robinson character Additional Voices (voice)
Katie Silverman character Additional Voices (voice)
Casey Simpson character Additional Voices (voice)
Claira Nicole Titman character Additional Voices (voice)
Jim Ward character Additional Voices (voice)
April Winchell character Additional Voices (voice)
