Ryan Reynolds character Wade Wilson / Deadpool / Juggernaut (voice) / Himself
Josh Brolin character Nathan Summers / Cable
Morena Baccarin character Vanessa Carlysle
Julian Dennison character Russell Collins / Firefist
Zazie Beetz character Neena Thurman / Domino
T. J. Miller character Jack Hammer / Weasel
Leslie Uggams character Blind Al
Karan Soni character Dopinder
Brianna Hildebrand character Ellie Phimister / Negasonic Teenage Warhead
Jack Kesy character Black Tom Cassidy
Eddie Marsan character Headmaster
Shiori Kutsuna character Yukio / Pinkie Pie
Stefan Kapičić character Piotr Rasputin / Colossus (voice)
Randal Reeder character Buck
Nikolai Witschl character Head Orderly Frye
Thayr Harris character Sergei Valishnikov
Rob Delaney character Peter
Lewis Tan character Gaveedra-Seven / Shatterstar
Bill Skarsgård character Axel Cluney / Zeitgeist
Terry Crews character Jesse Aaronson / Bedlam
Brad Pitt character Telford Porter / Vanisher
Paul Wu character Hong Kong Boss
Robert Maillet character Sluggo
Alan Tudyk character Luke, Redneck #1
Matt Damon character Redneck #2
Michasha Armstrong character SWAT Captain (School)
Joe Doserro character Bus Driver
Hayley Sales character Cable's Wife
Islie Hirvonen character Hope, Cable's Daughter
Jagua Arneja character Tree Trimmer #1
Gerry South character Tree Trimmer #2
Mike Dopud character Prison Guard
Luke Roessler character Cereal Kid
Andy Canete character Neighbour #1
Tanis Dolman character Neighbour #2
Eleanor Walker character Neighbour #3
Hunter Dillon character Branding Boy
Sala Baker character Older Russell Collins / Firefist
Sonia Sunger character News Reporter (Irene)
Paul Wernick character News Cameraman
Rhett Reese character News Helicopter Pilot
Abiola Uthman character Chinook Pilot
Tony Bailey character Black Tom Gang Member
David Cook character Priest
Alex Kliner character Park Bench Couple
Elaine Kliner character Park Bench Couple
David Leitch character Ground Church Mutant
Alicia Morton character Vocalist on 'Tomorrow' (singing voice)
Fred Savage character Fred Savage
Valencia Budijanto character Zoo Kid (uncredited)
Lisa Bunting character Child Protection Worker (uncredited)
Miles Ellis character Waving Prisoner (uncredited)
Sean Gislingham character Sammy (uncredited)
Lars Grant character Prison Guard 96S (uncredited)
Sam Hargrave character DMC Guard (uncredited)
Nicholas Hoult character Beast (uncredited)
Simon MacIntyre character Business Passerby (uncredited)
James McAvoy character Charles Xavier (uncredited)
Evan Peters character Quicksilver (uncredited)
Tye Sheridan character Cyclops (uncredited)
Alexandra Shipp character Storm (uncredited)
Kodi Smit-McPhee character Nightcrawler (uncredited)
Andréa Vawda character News Anchor (uncredited)
Scott Vickaryous character Thug (uncredited)
Dan Zachary character Mutant Prisoner (uncredited)
Hugh Jackman character Wolverine / Logan (archive footage)
