James Marsden character Diggs (voice)
Nick Nolte character Butch (voice)
Christina Applegate character Catherine (voice)
Bette Midler character Kitty Galore (voice)
Pascale Hutton character Jackie
Katt Williams character Seamus (voice)
Neil Patrick Harris character Lou (voice)
Sean Hayes character Mr. Tinkles (voice)
Wallace Shawn character Calico (voice)
Roger Moore character Tab Lazenby (voice)
Joe Pantoliano character Peek (voice)
Michael Clarke Duncan character Sam (voice)
Chris O'Donnell character Shane
Jack McBrayer character Chuck
Fred Armisen character Freidrich
Kiernan Shipka character Little Girl
Paul Rodríguez character Crazy Carlito (voice)
J.K. Simmons character Gruff K-9 (voice)
Grey DeLisle character Security Bulldog/Catherine's Niece/Cat Spy Analyst
Elizabeth Daily character Scrumptious / Patches / Catherine's Niece (voice)
Phil LaMarr character Paws / Cat Spy Analyst (voice)
Michael Beattie character Angus MacDougall (voice)
Jeff Bennett character Duncan MacDougall (voice)
Malcolm Stewart character Captain Flemming
Dawn Chubai character Reporter
Keith Dallas character Coit Tower Guard
Len Morganti character Rex (voice)
Betty Phillips character Cat Lady
Christopher L. Parson character Hep Cat / Cat Spy Analyst (voice)
Bumper Robinson character Cool Cat / Dog Killa / Cat Spy Analyst / Slim (voice)
Rick D. Wasserman character Rocky (voice)
Roger L. Jackson character Inmate Fat Cat (voice)
Bonnie Cahoon character Dog HQ PA / Catherine's Niece (voice)
André Sogliuzzo character Snobby K-9 (voice)
Carlos Alazraqui character Cat Gunner / Cat Spy Analyst (voice)
Grey DeLisle character Security Bulldog / Catherine's Niece / Cat Spy Analyst (voice)
Ingrid Tesch character Mom
Amitai Marmorstein character Playland Worker
Robert Hewko character Old Man
Mark Burgess character Used Car Salesman
Sage Brocklebank character Park Patron
