Matt Lucas character Franklin Franklin
Juno Temple character Simone
James Caan character Mr. Allspice
Dolph Lundgren character Dr. Sage Mennox
Billy Crystal character Burt Walnut
Peter Stormare character Dr. Olivetti
DJ Qualls character Artie
Johnny Knoxville character Tommy Balls
Rebel Wilson character Rocky
Rosie Perez character Ms. Baker
Angela Lindvall character Lisa
Tara Holt character Amber
James Marsden character Bernard Franklin
Saffron Burrows character Francine
David Koechner character Detective O'Grady
Noel Gugliemi character Dog Walker
Ned Bellamy character EMT / Daniel
