Drew Barrymore character Chloe (voice)
Piper Perabo character Rachel Ashe Lynn
Andy García character Delgado (voice)
George Lopez character Papi (voice)
Paul Rodríguez character Chico (voice)
Plácido Domingo character Monte (voice)
Edward James Olmos character Diablo (voice)
Loretta Devine character Delta (voice)
Jamie Lee Curtis character Aunt Viv
Luis Guzmán character Chucho (voice)
Eddie 'Piolin' Sotelo character Rafa (voice)
Carlos Juvera character Tomás (voice)
Grey DeLisle character Mother Dog (voice)
Manolo Cardona character Sam Cortez
Leslie Mann character Bimini (uncredited)
Cheech Marin character Manuel (voice)
Michael Urie character Sebastian (voice)
José María Yázpik character Vasquez
Maury Sterling character Rafferty
Jesús Ochoa character Officer Ramirez
Eugenio Derbez character Store Owner
Omar Leyva character Ranger
Naomy Romo character Ranger
Ali Hillis character Angela
Marguerite Moreau character Blair
Nick Zano character Bryan
Gina Gallego character Shelter Director
Alberto Reyes character Bellman
Brandon Keener character Waiter
Sal Lopez character Ring Announcer
Giovanna Acha Aleman character Museum Guide
Jack Plotnick character Dog Nanny
Randall England character Butler
