Tom Cruise character Barry Seal
Sarah Wright character Lucy Seal
Domhnall Gleeson character Monty Schafer
Alejandro Edda character Jorge Ochoa
Jesse Plemons character Sheriff Downing
Connor Trinneer character George W. Bush
Mauricio Mejía character Pablo Escobar
Jayma Mays character Dana Sibota
Lola Kirke character Judy Downing
April Billingsley character Jenny
Jayson Warner Smith character Bill Cooper
William Mark McCullough character Pete Dubois
Lara Grice character Female Reporter (uncredited)
Frank Licari character ATF Special Agent Franks
Jed Rees character Louis Finkle
Caleb Landry Jones character JB
Benito Martinez character James Rangel
Justice Leak character Agent Winter
Sharon Conley character DEA Agent Grace (uncredited)
Mike Pniewski character Willie
Robert Pralgo character Gary
E. Roger Mitchell character Agent Craig McCall
Morgan Hinkleman character Christina Seal
Courtney Lakin character Stewardess
Chris Gann character Donor #2 (uncredited)
Fredy Yate Escobar character Carlos Lehder
Robert Farrior character Oliver North
Alberto Ospino character Manuel Noriega
Felipe Bernedette character Translator
Daniel Lugo character Adolfo Calero
Lauren Boyd character Secretary
Nancy Reagan character Herself (archive footage)
Lauren Revard character Teller
Marcus Hester character Parka
Alex Collins character ATF #1
Scott Poythress character ATF #2
Alpha Trivette character Judge Linkletter
Kevin L. Johnson character Agent Horace Wainwright
DeVere Jehl character Plain Clothed Man
Emilio Sierra character Héctor (Colombian Driver)
Leon Lamar character Elderly Man
Maria Howell character NSC Woman
Darla Delgado character Customs Agent
Mickey Sumner character North's Aide Fawn Hall
Daniel Thomas May character CIA Man
Chloe Swan Sparwath character LeAnn
Alex Quarles character Aaron
Trip McCarthy character Dean
Zachary Powell character Dean
Jairo Ordoñez character Scar
Matt Mercurio character FBI Analyst
Ronald Reagan character Himself (archive footage)
Kayla Perkins character Waitress (uncredited)
Michael Mercaldi character Sandinista (uncredited)
Patti Schellhaas character Airplane Passenger (uncredited)
Dan Southworth character Agent Winters (Uncredited)
