Storm Reid character Meg Murry
Oprah Winfrey character Mrs. Which
Lyric Wilson character Young Meg
Rowan Blanchard character Veronica Kiley
Reese Witherspoon character Mrs. Whatsit
Mindy Kaling character Mrs. Who
Levi Miller character Calvin O'Keefe
Deric McCabe character Charles Wallace Murry
Chris Pine character Dr. Alex Murry
Gugu Mbatha-Raw character Dr. Kate Murry
Zach Galifianakis character The Happy Medium
Michael Peña character Red
André Holland character Principal Jenkins
Bellamy Young character Camazotz Woman
David Oyelowo character The It (voice)
Conrad Roberts character Elegant Man
Yvette Cason character Mrs. Teacher
Will McCormack character Mr. Teacher
Daniel MacPherson character Calvin's Father
Akemi Look character Air Force Officer
Tim Kang character School Superintendent
Michele Norris character Radio News Broadcaster (voice)
Claire Montwill character Student
Catelynn Brown character Meg Double
Ariyah Brown character Meg Double
Losa Fifita character Meg Double
Joyce Larkin character Mrs. Who Double
Teonee Motley character Mrs. Which Double
Jessica Rockwell character Mrs. Whatsit Double
Oz Kalvan character Charles Wallace Double
Isaac Ordonez character Charles Wallace Double
Kai Miller character Charles Wallace Double
Leighton Leevard character Charles Wallace Double
Guillaume Seeleuthner character Charles Wallace Double
Jacob Eddington character Charles Wallace Double
Easton Tath character Baby Charles Wallace
Giselle Paredes character Baby Charles Wallace
