Joseph Gordon-Levitt character Adam Lerner
Seth Rogen character Kyle Hirons
Anna Kendrick character Katherine McKay
Bryce Dallas Howard character Rachael
Anjelica Huston character Diane Lerner
Serge Houde character Richard Lerner
Andrew Airlie character Dr. Ross
Sugar Lyn Beard character Susan
Matt Frewer character Mitch
Philip Baker Hall character Alan
Donna Yamamoto character Dr. Walderson
Yee Jee Tso character Dr. Lee
Sarah Smyth character Jenny
Peter Kelamis character Phil
Jessica Parker Kennedy character Jackie
Daniel Bacon character Dr. Phillips
P. Lynn Johnson character Bernie
Laura Bertram character Claire
Matty Finochio character Ted
Marie Avgeropoulos character Allison
Luisa D'Oliveira character Agabelle Loogenburgen
Veena Sood character Nurse Stewart
Andrea Brooks character Attractive Woman #2
Beatrice King character Pretty Girl
Chilton Crane character Mother on the Bus
Lauren Miller character Bodie
Jason Vaisvila character Cute Guy with Dreads
Brent Sheppard character Minister
Stephanie Belding character Friendly Nurse
Ryan W. Smith character Joe
William 'Big Sleeps' Stewart character George
Amitai Marmorstein character Young Person on the Bus
Will Reiser character Greg
Christopher De-Schuster character Art Gallery Patron
Stephen Colbert character Himself (archive footage)
Tom MacNeill character Office Staff (uncredited)
Cameron K. Smith character Chemo Patient (uncredited)
D.C. Douglas character Live Volcano Reporter (voice)
